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Related Experiment Videos

A digital method for computing target margins in radiotherapy

J L Bedford1, G S Shentall

  • 1Joint Department of Physics, Institute of Cancer Research, Sutton, Surrey, United Kingdom. j.bedford@icr.ac.uk

Medical Physics
|March 21, 1998
PubMed
Summary
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Computer methods define radiotherapy planning target volumes from gross tumor volumes. A 3D margin is essential for 3D conformal planning to prevent underdosing tumor extremities, unlike 2D planning.

Area of Science:

  • Medical Physics
  • Radiation Oncology
  • Computational Biology

Background:

  • Accurate determination of planning target volume (PTV) from gross tumor volume (GTV) is critical for effective radiotherapy.
  • Conventional and conformal radiotherapy planning requires precise definition of target volumes to encompass microscopic disease and account for uncertainties.

Purpose of the Study:

  • To present computer methods for deriving PTV from GTV in both 2D and 3D radiotherapy planning.
  • To describe methods for calculating anisotropic margins in 2D and 3D to account for setup uncertainties and organ motion.
  • To evaluate the adequacy of 2D versus 3D margins in different planning scenarios.

Main Methods:

  • Projection of GTV outlines onto a transverse plane for 2D visualization and margin addition.

Related Experiment Videos

  • Anisotropic margin calculation in 2D and 3D to account for directional setup uncertainties.
  • Automatic calculation of PTV regions, demonstrated using a prostate cancer case.

    • Main Results:

    • A 2D margin added to projected GTV is sufficient for 2D treatment planning.
    • A fully 3D anisotropic margin applied to the GTV is necessary for 3D conformal planning.
    • Failure to use a 3D margin in 3D planning can lead to underdosing tumor extremities.

    Conclusions:

    • Computer-aided methods facilitate accurate PTV delineation for radiotherapy.
    • The dimensionality of the margin (2D vs. 3D) is crucial for ensuring adequate target coverage in conformal radiotherapy.
    • 3D conformal planning necessitates a 3D margin strategy to optimize dose delivery and clinical outcomes.