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[Certain aspects of the pathogenesis and prophylactic treatment of hypertensive crises]
Insights
Essential hypertension with crises involves central nervous system dysfunction, particularly in the hypothalamic and brain stem areas. Targeted therapy and CNS support are crucial for crisis prevention in hypertensive patients.
Area of Science:
- Neurology
- Cardiology
- Endocrinology
Context:
- Essential hypertension with crises presents complex clinical challenges.
- Understanding the interplay between the central nervous system (CNS) and neuro-humoral systems is vital.
- Investigating the functional state of the CNS in hypertensive patients is crucial for effective management.
Purpose:
- To analyze the clinical features of essential hypertension with crises.
- To examine changes in the functional state of the central nervous system (CNS).
- To investigate alterations in human neuro-humoral systems.
Summary:
- Patients with frequent hypertensive crises exhibit significant electroencephalogram (EEG) changes, indicating hypothalamic and brain stem reticular formation dysfunction.
- Clinical presentation includes astheno-neurotic disorders, autonomic dysfunction, and cerebral angiodystonic disturbances.
- Pathogenetically substantiated, differentiated therapy is essential for crisis prevention.
Impact:
- Highlights the importance of CNS endurance enhancement for hypertensive patients.
- Emphasizes improving cerebral circulation and metabolic processes.
- Underscores the need for correcting dishormonal disorders in managing hypertensive crises.
Abstract:
The paper analyses the results of a study of the clinical peculiarities of the course of essential hypertension with crises, of the changes in the functional state of the central nervous system, and of some neuro-humoral systems of the human body. In most of the patients tending to develope frequent crises distinct changes were noted in the EEG that indicate dysfunction of the hypothalamic zone and of the reticular formation of the brain stem, their clinical course being characterized by significant astheno-neurotic disorders with autonomous dysfunction and cerebral angiodistonic disturbances. For the prevention of crises it is essential to conduct a pathogenetically substantiated and highly differentiated systematic therapy, as well as special measures aimed at increasing the endurance of the central nervous system, improving the circulation and metabolic processes in the brain, decreasing tnd hypothalamic structures of the brain, and correcting the dishormonal disorders.