[Renal prostaglandins in DOCA-sodium chloride-induced hypertension in rats]

The changes in arterial pressure, sodium excretion, diuresis, and content of renal prostaglandins were studied in rats with COD-salt hypertension. The administration of DOC to rats with unilateral nephrectomy resulted in more distinct hypertension than in those with both kidneys preserved. Arterial pressure elevation was accompanied by a gradual reduction of renal prostaglandins concentration, the removal of one kidney causing an earlier and more distinct reduction of their content. Unilateral nephrectomy (without DOC administration) resulted in a reduction of prostaglandins concentration in the remaining kidney, but their total content in the medullar layer of this kidney practically did not change.