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Chelating agents as potential antitumorals: alpha-(N)-heterocyclic hydrazones and bis-alpha-(N)-heterocyclic
L Savini1, P Massarelli, L Chiasserini
1Dipartimento Farmaco Chimico Tecnologico, Università di Siena, Italy.
Farmaco (Societa Chimica Italiana : 1989)
|March 21, 1998
Abstract:
A number of pyruvic acid and methylpyruvate alpha-(N)-heterocyclic hydrazones has been synthesized. Bis-heterocyclic hydrazones were obtained from reaction with pyruvic carboxaldehyde. Some complexes of Ni(II) were prepared and characterized as neutral complexes. All these compounds have been evaluated for cytotoxicity against P388 and HL-60 leukemia.