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Related Experiment Videos

Andropause and the aging male

K Tserotas1, G Merino

  • 1Departamento de Obstetricia y Ginecología, Escuela de Medicina, Facultad de Medicina, Universidad de Panamá, Cindad de Panamá.

Archives of Andrology
|March 21, 1998
PubMed
Summary

Andropause symptoms are often psychological, not solely hormonal. While some hormone levels decrease with age, hormone replacement therapy is not recommended due to potential risks.

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Area of Science:

  • Endocrinology
  • Andrology
  • Gerontology

Background:

  • Andropause, often compared to female climacteric, presents complex symptoms.
  • Sexual function decline in aging men is multifactorial, not solely driven by hormonal shifts.

Purpose of the Study:

  • To investigate the hormonal and histological changes associated with aging in men.
  • To evaluate the role of hormonal fluctuations in age-related sexual dysfunction.
  • To assess the potential benefits and risks of androgen hormone replacement therapy.

Main Methods:

  • Histological examination of testicular tissue to assess cellular changes.
  • Measurement of various hormone levels including testosterone, dehydroepiandrosterone (DHEA), and others.
  • Analysis of age-related trends in sexual function and hormonal profiles.

Main Results:

  • Histological evidence of testicular aging includes reduced Leydig and Sertoli cells.
  • Testosterone and dehydroepiandrosterone (DHEA) levels decrease by approximately one-third.
  • Follicle stimulating hormone (FSH) and luteinizing hormone (LH) levels increase, while dehydrotestosterone (DHT) and estrogens remain unchanged.

Conclusions:

  • Age-related decline in sexual function is not primarily determined by hormonal changes.
  • Hormonal shifts observed in aging men do not warrant routine androgen hormone replacement therapy.
  • Potential severe side effects and lack of long-term data preclude recommendations for androgen therapy.

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