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Effect of antibiotic therapy in asthenozoospermic men associated with increased agglutination and minimal

S Carranza-Lira1, K Tserotas, C Morán

  • 1Gynecologic Endocrinology and Andrology Section, Hospital de Ginecología y Obstetricia Luis Castelazo Ayala, Instituto Mexicano del Seguro Social, México D.F.

Archives of Andrology
|March 21, 1998
PubMed

Insights

Antibiotic treatment for male infertility due to infection can alter sperm parameters. Ciprofloxacin and trimethoprim-sulfamethoxazole affected sperm morphology and motility in patients with asthenozoospermia.

Area of Science:

  • Reproductive Medicine
  • Andrology
  • Infectious Diseases

Background:

  • Asthenozoospermia, characterized by reduced sperm motility, can be associated with semen analysis suggestive of infection.
  • Identifying effective treatments for infection-related male infertility is crucial for reproductive health.

Purpose of the Study:

  • To investigate the effects of two common antibiotic regimens on semen parameters in patients with asthenozoospermia and suspected genital tract infection.
  • To compare the impact of ciprofloxacin versus trimethoprim-sulfamethoxazole on sperm density, morphology, viability, motility, and other seminal characteristics.

Main Methods:

  • A randomized study involving thirteen patients diagnosed with asthenozoospermia and signs of infection.
  • Patients were assigned to receive either ciprofloxacin or trimethoprim-sulfamethoxazole for 14 days, with their partners receiving the same treatment.
  • Semen analysis was performed before and after antibiotic administration to assess changes in sperm parameters.

Main Results:

  • A significant decrease in morphologically normal sperm was observed in the ciprofloxacine group post-treatment.
  • An increase in sperm with grade III motility was noted in the trimethoprim-sulfamethoxazole group, though not statistically significant.
  • Antibiotic therapy demonstrated an impact on specific seminal parameters, including sperm morphology and motility.

Conclusions:

  • Antibiotic administration can modify key spermatic parameters in men with asthenozoospermia and suspected infection.
  • These findings suggest that antibiotic treatment, while targeting infection, may influence sperm quality, necessitating further research into optimal therapeutic strategies.

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