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Brainstem microstimulation differentially inhibits pudendal motoneuron reflex inputs

R D Johnson1, C H Hubscher

  • 1Department of Physiological Sciences, College of Veterinary Medicine and the University of Florida Brain Institute, Gainesville 32610-0144, USA.

Neuroreport
|March 21, 1998
PubMed
Summary
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Researchers discovered a new descending neural pathway from the medullary reticular formation (MRF) to spinal cord circuits controlling perineal muscles. This finding may explain reproductive issues after spinal cord injuries.

Area of Science:

  • Neuroscience
  • Urology
  • Reproductive Medicine

Background:

  • Sensory signals from the genitourinary tract reach spinal cord reflex circuits and the medullary reticular formation (MRF).
  • The precise neural pathways linking the MRF to genitourinary sensory reflexes remain largely uncharacterized.

Purpose of the Study:

  • To investigate the functional descending connections between the MRF and sensory inputs of the pudendal motoneuron reflex circuitry.
  • To determine the role of the MRF in modulating pudendal motoneuron reflex discharges (PMRD).

Main Methods:

  • Experiments were conducted in anesthetized rats.
  • Microstimulation of the MRF was used to assess its effects on PMRD.
  • PMRD were elicited by stimulating the dorsal nerve of the penis and the pelvic nerve.

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Main Results:

  • Microstimulation of the MRF decreased the amplitude and increased the latency of PMRD elicited by dorsal penile nerve stimulation.
  • No significant effects were observed on PMRD elicited by pelvic nerve stimulation.
  • Bilateral microstimulation of the lateral paragigantocellular reticular nucleus yielded the most pronounced reflex depression.

Conclusions:

  • This study reports the first functional evidence of a descending connection from the MRF to pudendal motoneuron reflex pathways.
  • The MRF, particularly the lateral paragigantocellular reticular nucleus, plays a role in inhibiting genitourinary sensory reflexes.
  • Disruption of these descending connections following spinal cord injury may contribute to reproductive abnormalities.