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Related Experiment Videos

Skip lesions in temporal arteritis

R G Klein, R J Campbell, G G Hunder

    Mayo Clinic Proceedings
    |August 1, 1976
    PubMed
    Summary
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    Temporal arteritis skip lesions are common, found in 28% of patients. Even small, 330 mu foci of arteritis can exist in normal-appearing temporal artery biopsy specimens.

    Area of Science:

    • Vascular pathology
    • Rheumatology
    • Histopathology

    Background:

    • Temporal arteritis (giant cell arteritis) is a vasculitis affecting large arteries.
    • The presence and significance of "skip lesions" in temporal arteritis are poorly documented.
    • Skip lesions are isolated foci of inflammation within an artery.

    Purpose of the Study:

    • To document the existence and significance of skip lesions in temporal arteritis.
    • To determine the frequency of skip lesions in temporal artery biopsy specimens.
    • To provide recommendations for optimizing the detection of temporal arteritis.

    Main Methods:

    • Retrospective and prospective examination of temporal artery biopsy specimens.
    • Analysis of over 6,000 serial histologic sections from 60 patients.

    Related Experiment Videos

  • Identification of arteritis foci as short as 330 mu.

    • Main Results:

    • Skip lesions were identified in 17 of 60 patients (28%) with temporal arteritis.
    • Small foci of arteritis were found within otherwise normal-appearing arterial segments.
    • The study highlights the patchy nature of inflammation in temporal arteritis.

    Conclusions:

    • Skip lesions are a significant finding in temporal arteritis, occurring in over a quarter of cases.
    • Biopsying long arterial segments and examining multiple sections are crucial.
    • Contralateral temporal artery biopsy is recommended if initial frozen-section examination is normal.