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Enterococcus faecium bacteremia: does vancomycin resistance make a difference?

V Stosor¹, L R Peterson, M Postelnick

¹Department of Medicine, Northwestern University Medical School, Chicago, Ill 60611, USA.

Archives of Internal Medicine

|March 21, 1998

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Vancomycin-resistant Enterococcus faecium (VRE) bacteremia significantly reduces patient survival and increases healthcare costs. This resistant strain often arises from prolonged hospital stays in vulnerable individuals.

Area of Science:

Infectious Diseases
Bacteriology
Epidemiology

Background:

Enterococcus faecium is increasingly recognized for its vancomycin resistance.
Vancomycin-resistant Enterococcus faecium (VRE) poses a significant public health threat.

Purpose of the Study:

To investigate the epidemiological features of VRE bacteremia.
To assess the clinical impact of vancomycin resistance on patient outcomes.

Main Methods:

Retrospective analysis of 53 patients with Enterococcus faecium bacteremia.
Comparison of clinical characteristics and outcomes between vancomycin-susceptible (VSE) and VRE groups.

Main Results:

VRE bacteremia was associated with prior vancomycin use and indwelling bladder catheters.

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Survival rates were significantly lower for VRE (24%) compared to VSE (59%) bacteremia.

VRE infections led to longer hospitalizations and higher costs.

Conclusions:

Vancomycin resistance in Enterococcus faecium is linked to prolonged hospitalization and patient debilitation.
Vancomycin resistance negatively impacts survival and increases healthcare expenditures.