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[Behcet's disease]

E Ríhová1, M Havlíková, K Michalová

  • 1I. ocní klinika 1. LF UK, Praha.

Ceska a Slovenska Oftalmologie : Casopis Ceske Oftalmologicke Spolecnosti a Slovenske Oftalmologicke Spolecnosti
|March 21, 1998
PubMed
Summary

Behcet's disease frequently affects the eyes, with anterior uveitis being common. Serious complications include chronic cystoid macular edema, glaucoma, and vasculitis, often associated with the HLA B5 risk phenotype.

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Area of Science:

  • Ophthalmology
  • Rheumatology
  • Genetics

Context:

  • Behcet's disease (BD) is a multisystem inflammatory disorder.
  • Ophthalmological involvement is a significant cause of morbidity in BD.
  • This study focuses on patients diagnosed and treated at a specialized uveology clinic.

Purpose:

  • To evaluate diagnostic and therapeutic outcomes in patients with Behcet's disease.
  • To identify the prevalence of specific ocular manifestations and complications.
  • To correlate clinical findings with genetic risk factors.

Summary:

  • The study reviewed nine patients with Behcet's disease over a decade (1987-1996).
  • Anterior uveitis with hypopyon was more common than retinal vasculitis.
  • Key complications included chronic cystoid macular edema (CME), secondary glaucoma, and occlusive vasculitis.
  • Connective tissue and skin ulcerations were frequent findings.
  • The HLA B5 risk phenotype was present in two-thirds of patients.

Impact:

  • Highlights the significant ocular burden of Behcet's disease.
  • Emphasizes the importance of early diagnosis and management of ophthalmic complications.
  • Suggests a potential role for genetic screening (HLA B5) in risk assessment.

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