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A Simple Bioassay for the Evaluation of Vascular Endothelial Growth Factors
09:04

A Simple Bioassay for the Evaluation of Vascular Endothelial Growth Factors

Published on: March 15, 2016

Serum vascular endothelial growth factor levels in various liver diseases

F Akiyoshi1, M Sata, H Suzuki

  • 1Second Department of Medicine, Kurume University School of Medicine, Fukuoka, Japan.

Digestive Diseases and Sciences
|March 21, 1998
PubMed

Insights

Serum vascular endothelial growth factor (VEGF) levels differ across liver diseases. Acute hepatitis shows significantly higher VEGF, while cirrhosis shows lower levels, suggesting VEGF

Area of Science:

  • Hepatology
  • Biochemistry
  • Clinical Medicine

Background:

  • Vascular Endothelial Growth Factor (VEGF) plays a crucial role in angiogenesis and vascular permeability.
  • Its role in various liver diseases, including hepatitis and cirrhosis, requires further elucidation.
  • Understanding VEGF dynamics can offer insights into disease pathogenesis and progression.

Purpose of the Study:

  • To investigate the clinical significance of serum vascular endothelial growth factor (VEGF) in patients with diverse liver diseases.
  • To compare VEGF levels across different stages and types of liver conditions.
  • To explore the association between serum VEGF levels and hepatocyte regeneration.

Main Methods:

  • Serum VEGF levels were quantified using a chemiluminescence enzyme-linked immunosorbent assay (CLIA).
  • A cohort including patients with acute hepatitis (AH), chronic hepatitis (CH), cirrhosis (LC), fulminant hepatitis (FH), primary biliary cirrhosis (PBC), and autoimmune hepatitis (AIH) was studied.
  • VEGF levels were compared between patient groups and healthy controls.

Main Results:

  • Patients with acute hepatitis exhibited significantly elevated serum VEGF levels compared to controls (P < 0.001).
  • Cirrhosis patients displayed significantly lower serum VEGF levels than controls (P < 0.05).
  • Survivors of fulminant hepatitis showed increased VEGF levels during recovery, unlike non-survivors.

Conclusions:

  • Serum VEGF levels are significantly altered in various liver diseases, indicating its clinical relevance.
  • Elevated VEGF in acute hepatitis and reduced levels in cirrhosis suggest distinct roles in disease pathophysiology.
  • Serum VEGF may serve as a potential biomarker associated with the grade of hepatocyte regeneration.

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