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Related Experiment Videos

Melatonin administration and pituitary hormone secretion

I Kostoglou-Athanassiou1, D F Treacher, M J Wheeler

  • 1Department of Gynaecology, St. Thomas' Hospital, UMDS, London, UK.

Clinical Endocrinology
|March 24, 1998
PubMed
Summary
This summary is machine-generated.

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Altering melatonin rhythms impacts pituitary hormone secretion, advancing cortisol release and increasing prolactin. Melatonin also affects nocturnal vasopressin and oxytocin patterns in healthy men.

Area of Science:

  • Neuroendocrinology
  • Chronobiology
  • Hormone Research

Background:

  • The pineal gland's influence on pituitary function is debated.
  • Melatonin's role in adapting to environmental light-dark cycles is increasingly acknowledged.

Purpose of the Study:

  • To investigate how manipulating the melatonin rhythm affects pituitary hormone secretion in humans.

Main Methods:

  • A double-blind, placebo-controlled study involving ten healthy adult males.
  • Administration of 5 mg melatonin or placebo orally for 4 days at 1700 hours.
  • Measurement of serum cortisol, growth hormone, prolactin, and plasma vasopressin, oxytocin, melatonin, and other parameters over 24 hours.

Main Results:

  • Melatonin administration advanced the cortisol peak and increased prolactin release; growth hormone remained unaffected.

Related Experiment Videos

  • Nocturnal vasopressin increase duration was reduced, and nocturnal oxytocin increase was absent after melatonin administration.
  • Control studies showed normal nocturnal increases in vasopressin and oxytocin.

    • Conclusions:

    • Modifying the melatonin rhythm can influence neuroendocrine function.
    • Observed effects include altered nocturnal neurohypophysial hormone secretion patterns.
    • Augmented prolactin release and advanced cortisol peak indicate significant neuroendocrine modulation by melatonin.