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Sexual dysfunction induced by serotonin reuptake antidepressants

L A Labbate1, J Grimes, A Hines

  • 1Medical University of South Carolina, Charleston, USA.

Journal of Sex & Marital Therapy
|March 24, 1998
PubMed
Summary

Serotonin reuptake inhibitor (SRI) antidepressants like fluoxetine, sertraline, and paroxetine can negatively impact orgasm quality and increase orgasm delay. These findings highlight orgasm as a primary sexual function affected by SRIs.

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Area of Science:

  • Psychiatry
  • Pharmacology
  • Sexual Medicine

Background:

  • Selective serotonin reuptuptake inhibitors (SSRIs) are commonly prescribed for anxiety and depression.
  • SSRIs are known to cause sexual dysfunction, but prospective data are limited.

Purpose of the Study:

  • To prospectively evaluate the effects of three SSRIs on sexual function over three months.
  • To identify specific aspects of sexual function impacted by SSRI treatment.

Main Methods:

  • A prospective study involving 61 patients with anxiety or major depressive disorder.
  • Evaluation of libido, erection/lubrication, orgasm quality, orgasm delay, and sexual frequency using visual analog scales at baseline and monthly intervals.
  • Assessment of fluoxetine, sertraline, and paroxetine effects over a 3-month period.

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Main Results:

  • Orgasm quality significantly decreased and orgasm delay significantly increased for both men and women at months 1, 2, and 3 compared to baseline.
  • Erection scores showed a less dramatic decrease over time.
  • Lubrication, libido, and sexual frequency remained largely unchanged.
  • Anorgasmia was more prevalent in women than men during the first two months.

Conclusions:

  • Orgasm quality and delay are primary sexual functions adversely affected by SSRIs.
  • SSRI-induced sexual dysfunction, particularly anorgasmia, warrants clinical attention, especially in women.