Related Experiment Video

Updated: Feb 6, 2026

An Immature Murine Model of Reversible Unilateral Ureteral Obstruction
06:37

An Immature Murine Model of Reversible Unilateral Ureteral Obstruction

Published on: April 4, 2025

862

Vesico-ureteric reflux

P J Little

    The Medical Journal of Australia
    |May 1, 1976
    PubMed

    Insights

    Vesico-ureteric reflux is linked to kidney scarring, but infection

    Area of Science:

    • Pediatric Nephrology
    • Urology

    Background:

    • Vesico-ureteric reflux (VUR) is increasingly recognized as a factor in renal scar development.
    • The specific role of infection in VUR-associated renal scarring remains unclear.

    Purpose of the Study:

    • To explore the relationship between VUR and renal scarring.
    • To investigate the potential role of infection in scar formation.
    • To clarify the indications for surgical correction of VUR.

    Main Methods:

    • Review of existing literature on VUR, renal scarring, and infection.
    • Analysis of clinical data on patients undergoing surgical correction for VUR.

    Main Results:

    • A strong association exists between VUR and the development of renal scars.
    • The precise influence of infection on scar formation requires further investigation.
    • Surgical correction appears to prevent scar development in select pediatric cases.

    Conclusions:

    • Surgical intervention for VUR is likely most beneficial in infants and young children with severe reflux.
    • Further research is needed to elucidate the role of infection in renal scarring secondary to VUR.

    More Related Videos

    Surgical Models of Gastroesophageal Reflux with Mice05:19

    Surgical Models of Gastroesophageal Reflux with Mice

    Published on: August 25, 2015

    10.7K
    A Murine Model of Irreversible and Reversible Unilateral Ureteric Obstruction14:05

    A Murine Model of Irreversible and Reversible Unilateral Ureteric Obstruction

    Published on: December 20, 2014

    32.2K

    Related Concept Videos

    Gastroesophageal Reflux Disease I: Meaning and Pathophysiology01:29

    Gastroesophageal Reflux Disease I: Meaning and Pathophysiology

    Gastroesophageal Reflux Disease (GERD) involves the recurrent backflow of the stomach or duodenal contents into the esophagus, leading to troublesome symptoms and potential esophageal mucosal damage. Although GERD is often referred to as a disease, it is more accurately described as a syndrome, as it encompasses a range of symptoms and complications rather than a singular pathological entity, impacting a large number of individuals as the most prevalent upper gastrointestinal problem. Roughly...
    1.7K
    Gastroesophageal Reflux Disease II: Clinical Features and Management01:29

    Gastroesophageal Reflux Disease II: Clinical Features and Management

    Gastroesophageal reflux disease, or GERD, is a persistent medical condition that affects many individuals worldwide. Its clinical manifestations can vary greatly, making diagnosis and management challenging for healthcare professionals. The following is a comprehensive overview of the clinical manifestations, assessment, and management strategies for GERD.
    Clinical Manifestations
    GERD presents itself in a multitude of ways, with symptoms varying from person to person. The hallmark symptoms are...
    952
    Acids, Bases and Neutralization Reactions03:26

    Acids, Bases and Neutralization Reactions

    An acid-base reaction is one in which a hydrogen ion, H+, is transferred from one chemical species to another. Such reactions are of central importance to numerous natural and technological processes, ranging from the chemical transformations within cells or lakes and oceans to the industrial-scale production of fertilizers, pharmaceuticals, and other substances essential to the society.
    63.8K