Related Experiment Videos
Age-associated mosaicism and polyploidy in Down's syndrome
B Borsatto1, M de A Smith, E M Garcez
1Departamento de Morfologia, Disciplina de Genética, UNIFESP-Escola Paulista de Medicina, Sao Paulo, Brazil.
Mechanisms of Ageing and Development
|March 24, 1998
Abstract:
Age-related increases in the frequencies of cells with chromosome 21 loss and of polyploid cells were documented in short-term peripheral blood lymphocyte cultures from 54 patients with Down's syndrome (DS), ages 0 to 48 years. The polyploid data, together with previous work from this laboratory with non-DS subjects, suggest that this may be a useful indicator of aging in lymphocytes.