Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

The chick/quail chimeric system: a model for early cerebellar development

M Hallonet1, R M Alvarado-Mallart

  • 1Laboratoire d'embryologie cellulaire et moléculaire du CNRS et du Collèe de France, Paris, France.

Perspectives on Developmental Neurobiology
|January 1, 1997
PubMed
Summary

The chick/quail chimeric system aids in understanding cerebellar development. This research redefines cerebellar origins, explores the role of the En-2 gene in cerebellar specification, and examines the development of cortical cerebellar cells.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Genitocrural Island Perforator Flap (GIP-Flap): An ideal surgical technique for covering uni- or bilateral vulvar loss tissue.

Annales de chirurgie plastique et esthetique·2023
Same author

Nerve endings on the intramuscular tendons of cat extraocular muscles.

Neuroscience letters·2009
Same author

[Formation of the boundary between the midbrain and the hindbrain: involvement of Otx2 and Gbx2 genes].

Journal de la Societe de biologie·2001
Same author

The chick/quail transplantation model to study central nervous system development.

Progress in brain research·2001
Same author

Pax6 modulates the dorsoventral patterning of the mammalian telencephalon.

The Journal of neuroscience : the official journal of the Society for Neuroscience·2000
Same author

Direct action of the nodal-related signal cyclops in induction of sonic hedgehog in the ventral midline of the CNS.

Development (Cambridge, England)·2000

Area of Science:

  • Developmental Neuroscience
  • Neurobiology
  • Genetics

Background:

  • The chick/quail chimeric system is a valuable tool for studying central nervous system development.
  • Cerebellar ontogenesis involves complex processes requiring detailed investigation.

Purpose of the Study:

  • To explore cerebellar development using the chick/quail chimeric system.
  • To redefine the localization of the cerebellar primordium.
  • To investigate the role of the En-2 gene in cerebellar specification and the organizing capacity of the En-2 expressing neuroepithelium.
  • To reexamine the origin and settling of cortical cerebellar cells, including granule cells, molecular layer interneurons, and Purkinje cells.

Main Methods:

  • Utilizing the chick/quail chimeric system for experimental embryology.

Related Experiment Videos

  • Performing partial cerebellar grafts in chimeric embryos.
  • Analyzing the developmental processes of cerebellar primordium and cortical cell types.

    • Main Results:

    • Redefinition of the cerebellar primordium localization in the early neural tube, suggesting multiple morphogenetic origins.
    • Demonstration that the En-2 expressing cerebellar neuroepithelium can function as an organizer.
    • Insights into the origin and settling patterns of granule cells, molecular layer interneurons, and Purkinje cells.

    Conclusions:

    • The chick/quail chimeric system provides powerful insights into cerebellar development.
    • Cerebellar development is influenced by the localization of its primordium and the organizing role of specific genes like En-2.
    • Further understanding of the cellular origins and migration patterns within the cerebellar cortex is achieved.