Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Mouse Models of Cancer Study02:43

Mouse Models of Cancer Study

Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Benefits of Applications of Chlorothalonil for the Control of Black Mold of Tomato.

Plant disease·2019
Same author

Cerebellar contribution to higher and lower order rule learning and cognitive flexibility in mice.

Neuroscience·2016
Same author

Impaired hypercarbic and hypoxic responses from developmental loss of cerebellar Purkinje neurons: implications for sudden infant death syndrome.

Cerebellum (London, England)·2014
Same author

Critical evaluation of transcription factor Atf2 as a candidate modulator of alcohol preference in mouse and human populations.

Genetics and molecular research : GMR·2013
Same author

19p13.2 microduplication causes a Sotos syndrome-like phenotype and alters gene expression.

Clinical genetics·2011
Same author

High-throughput behavioral phenotyping in the expanded panel of BXD recombinant inbred strains.

Genes, brain, and behavior·2009

Related Experiment Video

Updated: Jul 23, 2026

A Simple Composite Phenotype Scoring System for Evaluating Mouse Models of Cerebellar Ataxia
07:33

A Simple Composite Phenotype Scoring System for Evaluating Mouse Models of Cerebellar Ataxia

Published on: May 21, 2010

Cerebellar mutant mice and chimeras revisited

R J Mullen1, K M Hamre, D Goldowitz

  • 1Department of Neurobiology and Anatomy, University of Utah School of Medicine, Salt Lake City 84132, USA.

Perspectives on Developmental Neurobiology
|January 1, 1997
PubMed
Summary

Chimeric mice reveal gene function in cerebellar development. Studying reeler, weaver, and staggerer mutants using chimera technology clarifies gene product roles in the cerebellum.

Area of Science:

  • Neuroscience
  • Developmental Biology
  • Genetics

Background:

  • Neurological mutant mice are crucial for understanding cerebellar gene function.
  • Chimeric mice, combining normal and mutant cells, help pinpoint gene action sites and cell interactions.
  • Three key cerebellar mutant genes (reeler, weaver, staggerer) have been recently cloned and their products identified.

Purpose of the Study:

  • To review chimera studies on neurological mutant mice.
  • To integrate findings from chimera technology with recent gene cloning data.
  • To elucidate the primary site of gene action for reeler, weaver, and staggerer mutations.

Main Methods:

  • Utilizing experimental chimeric mice composed of normal and mutant cells.
  • Analyzing the cellular composition and organization of mutant cerebella in chimeras.

More Related Videos

T-maze Forced Alternation and Left-right Discrimination Tasks for Assessing Working and Reference Memory in Mice
17:45

T-maze Forced Alternation and Left-right Discrimination Tasks for Assessing Working and Reference Memory in Mice

Published on: February 26, 2012

Validation of a Mouse Model to Disrupt LINC Complexes in a Cell-specific Manner
09:02

Validation of a Mouse Model to Disrupt LINC Complexes in a Cell-specific Manner

Published on: December 10, 2015

Related Experiment Videos

Last Updated: Jul 23, 2026

A Simple Composite Phenotype Scoring System for Evaluating Mouse Models of Cerebellar Ataxia
07:33

A Simple Composite Phenotype Scoring System for Evaluating Mouse Models of Cerebellar Ataxia

Published on: May 21, 2010

T-maze Forced Alternation and Left-right Discrimination Tasks for Assessing Working and Reference Memory in Mice
17:45

T-maze Forced Alternation and Left-right Discrimination Tasks for Assessing Working and Reference Memory in Mice

Published on: February 26, 2012

Validation of a Mouse Model to Disrupt LINC Complexes in a Cell-specific Manner
09:02

Validation of a Mouse Model to Disrupt LINC Complexes in a Cell-specific Manner

Published on: December 10, 2015

  • Reviewing existing literature on chimera studies of reeler, weaver, and staggerer mutants.

    • Main Results:

    • Chimera studies previously identified the primary site of gene action for reeler, weaver, and staggerer.
    • The identified gene products provide molecular context for the observed phenotypes.
    • Cell interactions in mutant cerebella can be better understood with known gene products.

    Conclusions:

    • Chimera technology has been instrumental in understanding cerebellar gene function.
    • The cloning of reeler, weaver, and staggerer genes validates and expands upon chimera study findings.
    • Integrating chimera data with molecular information enhances our understanding of cerebellar development and neurological disorders.