Malakoplakia of the prostate: a case report

Malakoplakia is an unusual chronic inflammatory disease that was first discovered in the urinary bladder but has subsequently been described in other sites. Characteristic gross and microscopic features of the lesions have been well described. The diagnosis of this tumor-like lesion can only be established by pathologic examination of the involved tissue. A case of prostatic malakoplakia with characteristic gross and microscopic features is reported in a 59-year-old man who presented with urinary frequency and a diminished urinary stream. Clinically the condition mimicked carcinoma of the prostate gland and the patient underwent a radical retropubic prostatectomy. Postoperative recovery was uneventful. The clinical and pathological findings, differential diagnosis and pertinent literature are reviewed. Preoperative needle biopsy or intraoperative frozen section for tissue diagnosis is recommended to avoid unnecessary radical surgery for this type of tumor-like lesion.