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Related Experiment Videos

Ki-1 lymphoma in two children

Y H Yang1, S T Jou, D T Lin

  • 1Department of Pediatrics, National Taiwan University Hospital, Taipei, Taiwan.

Journal of the Formosan Medical Association = Taiwan Yi Zhi
|March 24, 1998
PubMed
Summary

Childhood Ki-1 lymphoma, a rare cancer, presents unique challenges. Aggressive chemotherapy and bone marrow transplantation (BMT) offer treatment options for pediatric patients with this condition.

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Area of Science:

  • Pediatric Oncology
  • Hematology
  • Immunohistochemistry

Background:

  • Childhood Ki-1 lymphoma is infrequently documented in Taiwan.
  • This report details two pediatric cases managed at National Taiwan University Hospital.

Observation:

  • Two 8-year-old girls presented with distinct symptoms: one with a neck mass and hepatosplenomegaly, the other with joint pain and a pathologic fracture.
  • Histological examination revealed characteristic large, bizarre cells with pleomorphic nuclei and prominent nucleoli, confirmed by Ki-1 monoclonal antibody immunolabeling.

Findings:

  • Both patients underwent poly-regime chemotherapy followed by different types of bone marrow transplantation (BMT): autologous for patient 1 and allogeneic for patient 2.
  • Patient 1, despite radiotherapy and retinoic acid, had a poor response and succumbed to the disease within 2 years. Patient 2 achieved remission after allogeneic BMT, with follow-up at 26 months.

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Implications:

  • Childhood Ki-1 lymphoma diagnosis relies on specific clinical, histological, and immunological features.
  • Aggressive multi-agent chemotherapy combined with BMT represents a critical therapeutic strategy for pediatric Ki-1 lymphoma.