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Vancomycin-resistant enterococci: improving treatments

J Whittle1, E Queenan

  • 1University of Pittsburgh School of Medicine, USA.

Pennsylvania Medicine
|March 24, 1998
PubMed
Summary
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A study found that 63% of vancomycin orders violated Centers for Disease Control and Prevention (CDC) guidelines. Hospitals volunteered for this study as part of their strategy to control vancomycin-resistant enterococci (VRE).

Area of Science:

  • Infectious Diseases
  • Antimicrobial Resistance
  • Public Health

Background:

  • Vancomycin is a critical antibiotic for treating Staphylococcus aureus infections.
  • Emerging resistance to vancomycin in Staphylococcus aureus necessitates careful usage monitoring.
  • Vancomycin-resistant enterococci (VRE) control strategies include optimizing vancomycin use.

Purpose of the Study:

  • To detail a study on the appropriateness of vancomycin use.
  • To present findings specific to Pennsylvania hospitals participating in a multi-state initiative.
  • To highlight the role of vancomycin stewardship in preventing antibiotic resistance.

Main Methods:

  • Analysis of vancomycin order appropriateness in participating hospitals.
  • Voluntary participation in a 15-state study initiated in late 1995.

Related Experiment Videos

  • Integration of vancomycin use optimization with infection control measures.

    • Main Results:

    • A large study coordinated by the Health Care Financing Administration (HCFA) found 63% of vancomycin orders violated CDC guidelines.
    • Pennsylvania hospitals, as part of a voluntary 15-state study, participated in optimizing vancomycin use.
    • Hospitals recognized optimizing vancomycin use as key to VRE control.

    Conclusions:

    • Inappropriate vancomycin prescribing is widespread.
    • Optimizing vancomycin use is an essential component of antimicrobial stewardship.
    • Proactive infection control measures, including judicious antibiotic use, are crucial for combating resistance.