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Radical-scavenging antioxidants in pre-eclampsia and eclampsia
M Shaarawy1, A Aref, M E Salem
1Department of Obstetrics and Gynecology, Cairo University, Egypt.
Summary
Pre-eclampsia and eclampsia significantly deplete total antioxidant status, indicating increased oxidative stress during pregnancy. This highlights the consumption of radical-scavenging antioxidants in these conditions.
Area of Science:
- Obstetrics and Gynecology
- Biochemistry
- Pathophysiology
Background:
- Pre-eclampsia pathogenesis may involve increased free-radical activity.
- Antioxidant system responses in pre-eclampsia are not fully understood.
- Antioxidant status in eclampsia is largely unknown.
Purpose of the Study:
- To assess total antioxidant status in pre-eclampsia and eclampsia.
- To investigate the role of oxidative stress in pregnancy complications.
Main Methods:
- Studied 35 pre-eclampsia patients, 10 eclampsia patients, and 20 controls.
- Assayed serum total antioxidant status colorimetrically.
- Determined serum fibronectin using radial immunodiffusion.
Main Results:
- Total antioxidant status was significantly lower in mild pre-eclampsia (22% decrease), severe pre-eclampsia (40% decrease), and eclampsia (59% decrease) compared to controls.
- These findings indicate a propensity towards oxidative stress in these conditions.
- Serum fibronectin showed a negative correlation with total antioxidants.
Conclusions:
- Radical-scavenging antioxidants are consumed due to increased free-radical activity in pre-eclampsia.
- Free radicals contribute to endothelial dysfunction and renal injury.
- Correlations suggest a link between antioxidant status, fibronectin, and renal function.