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A randomized controlled trial of low-dose aspirin in women at risk from pre-eclampsia
R N Byaruhanga1, T Chipato, S Rusakaniko
1St. Francis Hospital Nsambya, Kampala, Uganda.
Objectives:
To determine whether low-dose aspirin reduces the incidence of pre-eclampsia, reduces perinatal mortality and improves birth weights in pregnant women considered at high risk of developing pre-eclampsia.
Method:
Two-hundred fifty subjects were recruited from the antenatal clinics at Harare Central Hospital with either a previous history of pregnancy-induced hypertension or pre-existing chronic hypertension and were randomized to receive either 75 mg of aspirin (ASA) or placebo (PLA).
Results:
Two-hundred thirty subjects (ASA, n = 113; PLA, n = 117) completed the trial. The odds of developing pre-eclampsia for those on aspirin was 0.72 times those on placebo (95% CI, 0.34-1.52). The mean birth weight was 2774 g for those on aspirin and 2694 g for those on placebo (P = 0.80). No difference was noted in the perinatal deaths (OR = 0.38; 95% CI, 0.10-1.20).
Conclusion:
Prophylactic use of aspirin was not associated with a significant effect on the major pregnancy outcomes assessed in this study.