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Related Experiment Videos

Second trimester abortion using intravaginal misoprostol

Y Herabutya1, P O-Prasertsawat

  • 1Department of Obstetrics and Gynaecology, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.

International Journal of Gynaecology and Obstetrics: the Official Organ of the International Federation of Gynaecology and Obstetrics
|March 24, 1998
PubMed
Summary

The 600-microg dose of intravaginal misoprostol is most effective for second-trimester abortions, achieving a 96% success rate. While side effects like nausea and diarrhea increased, they were mild and manageable.

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Area of Science:

  • Reproductive Medicine
  • Pharmacology

Background:

  • Second-trimester abortions require effective and safe induction methods.
  • Intravaginal misoprostol is a widely used agent for pregnancy termination.

Purpose of the Study:

  • To determine the optimal effective dose of intravaginal misoprostol for inducing second-trimester abortions.
  • To evaluate the efficacy and safety of different misoprostol dosages.

Main Methods:

  • A randomized study involving 150 pregnancies.
  • Intravaginal misoprostol administered in 200-microg, 400-microg, and 600-microg doses at 12-hour intervals.

Main Results:

  • The 48-hour successful abortion rates were 70.6%, 82%, and 96% for the respective doses.
  • Mean induction-to-abortion intervals decreased with higher doses (45.0h to 22.3h).

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  • Higher doses correlated with increased rates of nausea, vomiting, diarrhea, and temperature elevation, though side effects were mild.

    • Conclusions:

    • The 600-microg dose demonstrated superior efficacy for second-trimester abortion induction.
    • Despite increased side effects, the 600-microg dose is recommended due to its higher success rate and acceptable side effect profile.