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Related Experiment Videos

The mouse Hoxc11 gene: genomic structure and expression pattern

S L Hostikka1, M R Capecchi

  • 1Department of Human Genetics, University of Utah School of Medicine, Salt Lake City 84112-5331, USA.

Mechanisms of Development
|March 24, 1998
PubMed
Summary
This summary is machine-generated.

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The mouse Hoxc11 gene

Area of Science:

  • Developmental Biology
  • Genetics
  • Molecular Biology

Background:

  • The Hox complex comprises 39 genes in four linkage groups (A-D) in mice and humans.
  • Most Hox genes are characterized, but 5' members of the Hox C group are not fully understood.

Purpose of the Study:

  • To characterize the primary and genomic structure of the mouse Hoxc11 gene.
  • To determine the expression pattern of the mouse Hoxc11 gene during embryonic development.

Main Methods:

  • Gene structure determination (primary and genomic).
  • Messenger RNA (mRNA) expression analysis in developing mouse embryos.

Main Results:

  • The Hoxc11 gene encodes a 304 amino acid protein from a 2.2 kb transcript (two exons).

Related Experiment Videos

  • Hoxc11 mRNA is detected in posterior embryonic regions from 9.5 days gestation.
  • Expression observed in neural tube, ganglia, prevertebrae, hindlimbs, developing kidneys, and genitalia.

    • Conclusions:

    • Hoxc11 plays a role in the posterior development of the mouse embryo.
    • Specific expression patterns suggest involvement in kidney and genital development.
    • Detailed characterization of Hoxc11 provides insight into Hox C group gene function.