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Optimum dialysate calcium concentration during maintenance hemodialysis
Nephron
|January 1, 1976
Summary
A dialysate calcium concentration of 7 mg/100 ml is optimal for hemodialysis. This approach normalizes calcium levels, prevents bone loss, and reduces hyperparathyroidism risk.
Area of Science:
- Nephrology
- Mineral Metabolism
Background:
- Maintaining normal calcium and phosphate levels is crucial for hemodialysis patients.
- Secondary hyperparathyroidism and metastatic calcification are significant complications.
Purpose of the Study:
- To determine the optimal dialysate calcium concentration for hemodialysis.
- To evaluate the impact of dialysate calcium on calcium-phosphorus balance and bone health.
Main Methods:
- Clinical trials were conducted to assess the effects of a 7 mg/100 ml dialysate calcium concentration.
- Plasma calcium and phosphate levels were monitored throughout the study.
Main Results:
- A dialysate calcium concentration of 7 mg/100 ml effectively normalizes plasma-ionized calcium.
- This concentration offsets fecal calcium loss and prevents bone calcium loss.
- It reduces the risk of secondary hyperparathyroidism and metastatic calcification.
Conclusions:
- A dialysate calcium of 7 mg/100 ml is optimal for hemodialysis when phosphate is controlled and thrice-weekly dialysis is used.
- This concentration improves calcium balance, protects bone, and mitigates hyperparathyroidism and calcification risks.