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Plasma lipoprotein profiles change significantly during cardiac catheterization
T Miida1, H Otsuka, A Tsuchiya
1Department of Laboratory Medicine, Niigata University School of Medicine, Japan. miida@med.niigatau.ac.jp
Clinical Chemistry
|March 25, 1998
Summary
Lipoprotein profiles significantly change after cardiac catheterization in acute myocardial infarction patients. Avoid analyzing these profiles immediately after coronary angiography or angioplasty procedures.
Area of Science:
- Cardiology
- Clinical Biochemistry
- Medical Diagnostics
Background:
- Acute myocardial infarction (AMI) patients frequently undergo coronary angiography (CAG).
- The optimal timing for assessing lipoprotein profiles in AMI remains unclear.
- Potential alterations in lipoprotein profiles due to catheterization procedures require investigation.
Purpose of the Study:
- To determine if lipoprotein profiles change during cardiac catheterization procedures.
- To compare changes in lipoprotein profiles after coronary angiography (CAG) versus percutaneous transluminal coronary angioplasty (PTCA).
Main Methods:
- Serum lipid and apolipoprotein concentrations were measured in 65 AMI patients before and after catheterization.
- Heparin was administered at specific doses for CAG and PTCA procedures.
- Lipoprotein lipase mass was also assessed post-procedure.
Main Results:
- Significant decreases in cholesterol (9.4%) and triglycerides (53.1%) were observed post-catheterization.
- Apolipoprotein concentrations also showed significant reductions.
- Changes were more pronounced after PTCA compared to CAG.
- Lipoprotein lipase mass was significantly higher after PTCA than after CAG.
Conclusions:
- Lipoprotein profiles are altered by cardiac catheterization procedures.
- Emergent analysis of lipoprotein profiles immediately following CAG in AMI patients is not recommended.
- Procedure type (CAG vs. PTCA) influences the extent of lipoprotein profile changes.