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Roseocardin, a novel cardiotonic cyclodepsipeptide from Trichothecium roseum TT103
A Tsunoo1, M Kamijo, N Taketomo
1Meiji Institute of Health Science, Meiji Milk Products Co., Ltd., Kanagawa, Japan.
The Journal of Antibiotics
|March 25, 1998
Abstract:
A new cyclodepsipeptide, designated roseocardin, was isolated from the culture broth of Trichothecium roseum TT103. Roseotoxin B and destruxins A and B were also isolated during the same procedure. The structure of roseocardin was determined by EI-MS, NMR and X-ray crystallographic analysis. Roseocardin as well as the other cyclodepsipeptides were shown to produce positive inotropic effects on rat heart muscles.