Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Cardiovascular alterations in septic shock

J L Vincent1

  • 1Department of Intensive Care, Erasme University Hospital, Brussels, Belgium. jlvincen@resulb.ulb.ac.be

The Journal of Antimicrobial Chemotherapy
|March 25, 1998
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Core competencies in critical care for general medical practitioners in South Africa: A Delphi study.

The Southern African journal of critical care : the official journal of the Critical Care Society·2024
Same author

Proceedings of resources for optimal care of acute care and emergency surgery consensus summit Donegal Ireland.

World journal of emergency surgery : WJES·2017
Same author

Erratum to: Antimicrobials: a global alliance for optimizing their rational use in intra-abdominal infections (AGORA).

World journal of emergency surgery : WJES·2017
Same author

Preoperative abnormalities in serum sodium concentrations are associated with higher in-hospital mortality in patients undergoing major surgery.

British journal of anaesthesia·2015
Same author

Recent negative clinical trials in septic patients: maybe a good thing?

Minerva anestesiologica·2015
Same author

Elevated β-lactam concentrations associated with neurological deterioration in ICU septic patients.

Minerva anestesiologica·2014
Same journal

Favipiravir tissue distribution and inhibitory quotients in preclinical models: towards a pipeline for evidence-based antiviral repurposing.

The Journal of antimicrobial chemotherapy·2026
Same journal

A review of the randomized clinical trial results from the Staphylococcus aureus network adaptive platform (SNAP) meticillin-susceptible (MSSA) and penicillin-susceptible (PSSA) domains and CloCeBa.

The Journal of antimicrobial chemotherapy·2026
Same journal

Incidence and factors associated with subtherapeutic cefazolin levels among patients with severe infections.

The Journal of antimicrobial chemotherapy·2026
Same journal

Emerging resistance in staphylococci following long-term dalbavancin treatment for prosthetic joint infections.

The Journal of antimicrobial chemotherapy·2026
Same journal

Microbiology testing around the time of antibiotic initiation among residents of long-term care facilities.

The Journal of antimicrobial chemotherapy·2026
Same journal

Insights into the mechanisms underlying cell wall-active agents and gentamicin bactericidal synergism against Enterococcus faecalis.

The Journal of antimicrobial chemotherapy·2026
See all related articles

Sepsis causes cardiovascular issues like low vascular tone and poor heart contraction due to inflammatory mediators. Understanding these factors is key for future sepsis treatments.

Area of Science:

  • Cardiovascular pathophysiology
  • Sepsis research
  • Inflammatory mediator effects

Background:

  • Sepsis involves cardiovascular alterations, including decreased vascular tone and impaired myocardial contractility.
  • These changes are primarily driven by mediators released during the sepsis cascade.
  • Cytokines (e.g., tumor necrosis factor, interleukin-1) and secondary mediators (e.g., nitric oxide, oxygen free radicals) play significant roles.

Purpose of the Study:

  • To review current knowledge on factors contributing to cardiovascular alterations in sepsis.
  • To discuss the clinical implications of these cardiovascular changes.
  • To explore potential future treatment strategies for sepsis-induced cardiovascular dysfunction.

Main Methods:

  • Review of existing scientific literature on sepsis and cardiovascular effects.

Related Experiment Videos

  • Analysis of the roles of various mediators, including cytokines and free radicals.
  • Correlation of cardiovascular alterations with sepsis severity.

    • Main Results:

    • Cardiovascular alterations in sepsis are mediated by a complex interplay of cytokines and other inflammatory molecules.
    • Reduced vascular tone and myocardial depression are directly linked to the severity of the sepsis condition.
    • The identified mediators significantly impact cardiac function and vascular responsiveness.

    Conclusions:

    • Cardiovascular dysfunction is a critical component of sepsis pathophysiology.
    • Mediators like cytokines and nitric oxide are central to sepsis-induced cardiac and vascular changes.
    • Further research into these mediators may lead to novel therapeutic interventions for sepsis.