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Mouse annexin III cDNA, genetic mapping and evolution

M P Fernández1, N G Copeland, D J Gilbert

  • 1Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Oviedo, Spain. mpff@dwarf1.quimica.uniovi.es

Gene
|March 25, 1998
PubMed
Summary

Researchers characterized mouse annexin III cDNA, revealing its chromosomal location and evolutionary divergence. This study provides insights into annexin III

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Area of Science:

  • Molecular Biology
  • Genomics
  • Evolutionary Biology

Background:

  • Annexins are a conserved family of calcium-dependent phospholipid-binding proteins.
  • Annexin III (Anx3) function and evolutionary history remain less understood compared to other annexins.

Purpose of the Study:

  • To characterize the mouse annexin III (Anx3) cDNA sequence and gene locus.
  • To investigate the evolutionary relationships and divergence patterns of Anx3 within the annexin superfamily.

Main Methods:

  • Molecular sequencing of expressed sequence tag clones.
  • Chromosomal mapping of the Anx3 locus in mice.
  • Comparative analysis of protein-coding regions with homologous annexins.
  • Phylogenetic and phenetic analyses.

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Main Results:

  • The mouse Anx3 cDNA sequence was fully characterized, extending known untranslated regions and confirming intron 7's position relative to the human gene.
  • The Anx3 locus was mapped to mouse chromosome 5, situated between Areg and Fgf5.
  • Annexin III demonstrated low functional constraint and weak phylogenetic association, indicating rapid divergence from other annexins.
  • Phylogenetic data suggests a potential separation of annexin III from annexin XI around 317 million years ago.

Conclusions:

  • Mouse annexin III cDNA characterization provides a comprehensive genetic and genomic resource.
  • Annexin III exhibits unique evolutionary dynamics, diverging rapidly from other annexin subfamilies.
  • The estimated gene separation time offers a molecular clock for annexin evolution.