Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Nervous system Lyme disease

J J Halperin1

  • 1Department of Neurology, North Shore University Hospital, Manhasset, NY 11030, USA. halperin@nshs.edu

Journal of the Neurological Sciences
|March 25, 1998
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Diagnosis and management of acute encephalitis.

Handbook of clinical neurology·2017
Same author

Oral treatment of parenchymal central nervous system neuroborreliosis--are we there yet?

European journal of neurology·2014
Same author

Lyme borreliosis: the challenge of accuracy.

The Netherlands journal of medicine·2012
Same author

Nervous system Lyme disease.

The journal of the Royal College of Physicians of Edinburgh·2010
Same author

Analysis of a flawed double-blind, placebo-controlled, clinical trial of patients claimed to have persistent Lyme disease following treatment.

Minerva medica·2009
Same author

A critical appraisal of "chronic Lyme disease".

The New England journal of medicine·2007
Same journal

Distinguishing drug-target effects from natural lipid variation and incorporating imaging outcomes in Mendelian randomisation studies of multiple sclerosis.

Journal of the neurological sciences·2026
Same journal

Long-term social cognitive impairment after ischemic stroke: Frequency and association with lesion volume and location in an exploratory pilot study.

Journal of the neurological sciences·2026
Same journal

Subjective cognitive decline among U.S. Cancer survivors, 2017-2024: Prevalence, cancer-specific patterns, and associated factors.

Journal of the neurological sciences·2026
Same journal

Comment on "Comparative impact of mental and cardiovascular comorbidities on adverse outcomes in people with MS".

Journal of the neurological sciences·2026
Same journal

Comment on "Efficacy and safety of conventional immunosuppressant therapies in elderly patients with Neuromyelitis optica spectrum disorder: A target trial emulation study".

Journal of the neurological sciences·2026
Same journal

Increasing incidence of varicella-zoster virus meningitis in Japan, 2011-2022.

Journal of the neurological sciences·2026
See all related articles

Lyme disease, a tick-borne illness caused by Borrelia burgdorferi, affects multiple body systems. Early diagnosis and prompt antimicrobial treatment, like doxycycline or ceftriaxone, are key to managing this infectious disease.

Area of Science:

  • Infectious Diseases
  • Neurology
  • Rheumatology

Background:

  • Lyme disease is a multisystem infectious illness caused by Borrelia burgdorferi spirochetes.
  • Transmitted by Ixodes ticks, it is prevalent in North America, Europe, and Asia.
  • The disease commonly affects the heart, joints, and nervous system.

Purpose of the Study:

  • To provide an overview of Lyme disease, including its transmission, diagnosis, clinical manifestations, and treatment.
  • To highlight the complexities of diagnosing neuroborreliosis and the effectiveness of various diagnostic methods.
  • To discuss the efficacy of antimicrobial therapies for different stages and severities of Lyme disease.

Main Methods:

  • Review of existing literature on Lyme disease epidemiology, pathogenesis, clinical presentation, diagnostics, and treatment.

Related Experiment Videos

  • Emphasis on serologic testing, Western blots, and intrathecal antibody production for diagnosis.
  • Discussion of antimicrobial agents such as doxycycline, ceftriaxone, and cefotaxime.

    • Main Results:

    • Diagnosis can be challenging, but serologic testing with Western blot confirmation is useful.
    • Neurological involvement includes meningitis, cranial neuritis, radiculitis, encephalomyelitis, mononeuropathy multiplex, and encephalopathy.
    • Intrathecal antibody production is the most sensitive diagnostic marker for central nervous system involvement.
    • Most cases respond well to antimicrobial therapy, with oral doxycycline effective for meningitis and parenteral ceftriaxone/cefotaxime for severe cases.

    Conclusions:

    • Lyme disease requires careful diagnosis, especially when the nervous system is involved.
    • Prompt and appropriate antimicrobial treatment is crucial for successful patient outcomes.
    • Understanding the diverse clinical presentations and diagnostic nuances is essential for effective management.