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The effects of MK-801 on spatial working memory and within-session spatial learning

A M White1, P J Best

  • 1Department of Psychology and Center for Neuroscience Research, Miami University, Oxford, OH 45056, USA.

Pharmacology, Biochemistry, and Behavior
|March 25, 1998
PubMed
Summary

The NMDA receptor blocker MK-801 impaired spatial working memory at high doses but not short-term spatial learning. This suggests NMDA receptors are crucial for long-term, but not short-term, spatial information storage.

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Area of Science:

  • Neuroscience
  • Cognitive Psychology
  • Pharmacology

Background:

  • The N-methyl-D-aspartate (NMDA) receptor is implicated in learning and memory.
  • Understanding the NMDA receptor's role in different memory types is crucial for cognitive research.

Purpose of the Study:

  • To investigate the effects of the NMDA receptor antagonist MK-801 on spatial working memory and within-session spatial learning.
  • To differentiate the NMDA receptor's involvement in short-term versus long-term spatial information processing.

Main Methods:

  • Utilized a radial-arm maze task to assess spatial memory in subjects treated with varying doses of MK-801 (0.05, 0.10, 0.15 mg/kg).
  • Evaluated spatial working memory by analyzing errors during free-choice trials.
  • Assessed within-session spatial learning by comparing early versus late trials within a daily session.

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Main Results:

  • Only the highest dose of MK-801 (0.15 mg/kg) significantly impaired spatial working memory.
  • No tested dose of MK-801 affected the ability to learn spatial information within a single session.
  • These findings contrast with MK-801's known effects on cross-day spatial learning.

Conclusions:

  • The NMDA receptor appears essential for the consolidation of spatial information into long-term memory.
  • The NMDA receptor's role in spatial memory is dose-dependent and specific to memory duration.
  • This study highlights the differential involvement of NMDA receptors in short-term versus long-term spatial memory processes.