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Minocycline-induced scleral, dental, and dermal pigmentation
1Toronto East General and Orthopedic Hospital.
Purpose:
To report a case of scleral discoloration secondary to minocycline therapy.
Method:
Case report of a patient referred to a university-based cornea and external disease clinic.
Results:
The patient had been treated with oral minocycline therapy for adult facial acne for 12 years when she began to develop bilateral blue-gray discoloration of the sclera as well as of the teeth, hard palate, ears, nail beds, and skin.
Conclusions:
Chronic systemic minocycline therapy may induce scleral pigmentary changes. The mechanism of discoloration and the long-term natural history upon cessation of minocycline are unclear.
