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Squamous cell tumors and ocular prostheses

P C Campanella1, S H Goldberg, K Erlichman

  • 1Department of Ophthalmology, Penn State University College of Medicine, Hershey, Pennsylvania, USA.

Ophthalmic Plastic and Reconstructive Surgery
|March 26, 1998
PubMed
Summary
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Conjunctival squamous cell carcinoma, a rare tumor, can develop secondary to poorly fitting ocular prostheses, even after decades of use. New discharge or swelling warrants investigation beyond mechanical irritation.

Area of Science:

  • Ophthalmology
  • Oncology

Background:

  • Conjunctival squamous cell carcinoma (cSCC) is a rare malignancy.
  • It is typically associated with actinic damage and chronic irritation.

Observation:

  • This study reports two cases of cSCC developing in patients with long-term use of poorly fitting ocular prostheses.
  • Both patients had worn prostheses for over 40 years prior to tumor development.

Findings:

  • Histopathologic evaluation confirmed the squamous cell origin of the tumors.
  • One patient presented with metastasis to the ipsilateral parotid gland, an unusual finding for cSCC.
  • Poorly fitting prostheses were identified as a potential risk factor in both cases, with no other significant risk factors present.

Implications:

Related Experiment Videos

  • Long-term prosthetic wear, particularly with poor fit, may be an underrecognized risk factor for cSCC.
  • New onset of conjunctival discharge or eyelid swelling in patients with ocular prostheses should prompt thorough investigation for malignancy.
  • This highlights the importance of regular monitoring and prosthesis maintenance to prevent potential complications.