Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Multiple myeloma involving the orbit

A M Fay1, M L Leib, K S Fountain

  • 1Orbit and Plastics Service, Edward S. Harkness Eye Institute, New York, NY 10032, USA.

Ophthalmic Plastic and Reconstructive Surgery
|March 26, 1998
PubMed
Summary

Orbital plasmacytoma, a rare multiple myeloma complication, can occur even without high immunoglobulin levels. Early ophthalmic exams are crucial for timely diagnosis and effective treatment of this rare plasma cell malignancy.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Behavioural thermoregulation in the Australian fur seal (Arctocephalus pusillus doriferus).

Journal of thermal biology·2025
Same author

Peritoneal mesothelioma.

Current treatment options in oncology·2002
Same author

An animal model of lower eyelid spacer grafting with acellular dermis.

Ophthalmic plastic and reconstructive surgery·2001
Same author

Primary placement of a motility coupling post in porous polyethylene orbital implants.

Archives of ophthalmology (Chicago, Ill. : 1960)·2000
Same author

Ophthalmic plastic applications of acellular dermal allografts.

Ophthalmology·1999
Same author

Endocanalicular Nd: YAG laser dacryocystorhinostomy.

International ophthalmology clinics·1999

Area of Science:

  • Oncology
  • Ophthalmology
  • Hematology

Background:

  • Multiple myeloma is a plasma cell malignancy frequently causing skeletal damage.
  • Orbital involvement is an uncommon manifestation of multiple myeloma.
  • Established risk factors for orbital plasmacytoma are lacking.

Observation:

  • A rare case of multiple myeloma with orbital involvement is presented, notably without elevated serum immunoglobulins.
  • The patient exhibited kappa light chains in urine protein electrophoresis.
  • Orbital involvement was detected via plain-film roentgenography at initial diagnosis.

Findings:

  • The patient experienced a significant clinical response to external beam radiation therapy.
  • Early detection of orbital plasmacytoma can influence treatment strategies and patient outcomes.

Related Experiment Videos

  • Immunoprotein characteristics may help identify patients at risk for orbital spread.

    • Implications:

    • Thorough ophthalmic examinations are recommended for all multiple myeloma patients at diagnosis.
    • Early identification of orbital plasmacytoma may allow for safer and equally effective treatments.
    • Further research into risk factors associated with immunoglobulin subtypes is warranted.