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Urological dysfunctions and upper urinary tract involvement in multiple sclerosis patients
A Giannantoni1, G Scivoletto, S M Di Stasi
1I.R.C.C.S. Rehabilitation Hospital S. Lucia, Rome, Italy.
Neurourology and Urodynamics
|March 26, 1998
Summary
Multiple sclerosis (MS) patients with bladder issues show upper urinary tract (UUT) involvement. Early detection and management of UUT abnormalities are crucial for MS patients with bladder dysfunction.
Area of Science:
- Urology
- Neurology
- Nephrology
Background:
- Multiple sclerosis (MS) is a chronic neurological disease.
- Urinary tract dysfunction is a common complication in MS patients.
- Upper urinary tract (UUT) involvement in MS requires further investigation.
Purpose of the Study:
- To investigate UUT involvement in MS patients.
- To explore the relationship between UUT abnormalities and neurological/urological features in MS.
- To identify risk factors for UUT involvement in MS.
Main Methods:
- 116 MS patients underwent neurological and urological assessments.
- Urodynamic investigations were performed.
- Morphofunctional urinary tract studies included ultrasonography, voiding cystourethrography, and intravenous pyelography.
Main Results:
- Significant relationships were found between disease duration, pyramidal system score, detrusor contractions, bladder abnormalities, and UUT involvement.
- Pyramidal system score and bladder pathology were linked to UUT abnormalities (P = 0.03 and 0.0006).
- Maximum uninhibited detrusor contraction amplitude correlated significantly with UUT involvement (P = 0.002).
Conclusions:
- MS disease duration, bladder abnormalities, and detrusor overactivity are associated with UUT involvement.
- Regular urodynamic assessment and urinary tract imaging are vital for MS patients.
- Anticholinergic medications may help maintain detrusor relaxation and protect the UUT.