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A Primary Neuron Culture System for the Study of Herpes Simplex Virus Latency and Reactivation
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Herpesvirus in atherosclerosis and thrombosis: etiologic agents or ubiquitous bystanders?

A C Nicholson1, D P Hajjar

  • 1Department of Pathology, Center of Vascular Biology, Cornell University Medical College, New York, NY 10021, USA.

Arteriosclerosis, Thrombosis, and Vascular Biology
|March 26, 1998
PubMed

The role of herpesvirus infections in the pathogenesis of vascular diseases remains an enigma. Although there is abundant circumstantial evidence of a role for herpesviruses in atherosclerosis and related processes, a cause-and-effect relationship has yet to be definitively established. This article will review the pathological, molecular, and biochemical evidence supporting the hypothesis that herpesviruses are involved in the development of atherosclerosis, restenosis after coronary angioplasty, accelerated atherosclerosis in recipients of heart transplants, and the induction of a prothrombotic phenotype in vascular endothelial cells.

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