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Left ventricular Doppler diastolic filling patterns in patients with isolated left bundle branch block
A Sadaniantz1, L Saint Laurent
1Division of Cardiology, The Miriam Hospital, Brown University School of Medicine, Providence, Rhode Island 02906, USA.
Insights
Isolated left bundle branch block (LBBB) significantly alters diastolic filling patterns. Echocardiography revealed lower E-wave velocity and altered filling dynamics in LBBB patients compared to healthy controls.
Area of Science:
- Cardiology
- Cardiac Electrophysiology
- Echocardiography
Background:
- Left bundle branch block (LBBB) is a conduction abnormality affecting ventricular depolarization.
- Diastolic dysfunction can occur in various cardiac conditions, impacting ventricular filling.
- Understanding LBBB's specific impact on diastolic function is crucial for patient management.
Purpose of the Study:
- To investigate the effects of isolated left bundle branch block (LBBB) on diastolic filling patterns.
- To compare echocardiographic diastolic parameters between subjects with LBBB and healthy controls.
Main Methods:
- Echocardiography was used to assess diastolic filling patterns.
- Fourteen subjects with isolated LBBB and 16 healthy controls were evaluated.
- Key Doppler parameters including E-wave velocity, E/A ratio, and deceleration slope were measured.
Main Results:
- Subjects with LBBB demonstrated significantly lower maximum E-wave velocity compared to controls.
- The E/A ratio and deceleration time of the E wave were reduced in the LBBB group.
- Doppler-derived diastolic filling patterns were markedly altered in individuals with isolated LBBB.
Conclusions:
- Isolated LBBB significantly impacts left ventricular diastolic filling.
- These alterations in diastolic function may have clinical implications for patients with LBBB.
- Echocardiography is effective in detecting LBBB-induced changes in diastolic patterns.
Abstract:
To evaluate the effect of isolated left bundle branch block (LBBB) on diastolic filling patterns, we evaluated 14 subjects with isolated LBBB and 16 age- and sex-matched healthy subjects with normal ventricular conduction by echocardiography. Maximum E-wave velocity, E/A ratio, deceleration time of E wave, and the slope of deceleration of the E wave were lower in subjects with LBBB compared with subjects with normal ventricular conduction. Doppler filling patterns were significantly altered in subjects with isolated LBBB.