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Related Experiment Videos

Methamphetamine self-administration in the cat

R L Balster, M M Kilbey, E H Ellinwood

    Psychopharmacologia
    |April 15, 1976
    PubMed
    Summary

    Methamphetamine is a reinforcing drug in cats, as shown by their self-administration patterns. Intake varied over days, and dose affected response rates, similar to other species.

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    Area of Science:

    • Pharmacology
    • Neuroscience
    • Animal Behavior

    Background:

    • Understanding drug reinforcement mechanisms is crucial for addiction research.
    • Investigating stimulant self-administration in animal models provides insights into human drug use.

    Purpose of the Study:

    • To describe a procedure for studying intravenous drug self-administration in cats.
    • To assess methamphetamine as a reinforcer in feline subjects.
    • To examine the dose-response relationship of methamphetamine self-administration.

    Main Methods:

    • Cats received 24-hour access to intravenous methamphetamine (0.04 mg/kg/injection) or saline.
    • Response rates for drug versus saline reinforcement were compared.
    • Dose-effect of methamphetamine on self-administration was studied under limited access conditions.

    Main Results:

    • Cats showed significantly higher response rates for methamphetamine than for saline.
    • Self-administration patterns exhibited alternating periods of high and low drug intake.
    • Response rate as a function of methamphetamine dose per injection followed an inverted U-shaped curve.

    Conclusions:

    • Methamphetamine functions as a reinforcer in cats.
    • Intake patterns in cats resemble those observed in other species.
    • Dose significantly influences methamphetamine self-administration in cats.

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