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Holding chambers for pMDI use

H Matthys1, A Umile

  • 1Department of Medicine, University Hospital, Freiburg, Germany.

Drugs Under Experimental and Clinical Research
|January 1, 1997
PubMed
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The new JET spacer for pressurized metered-dose inhalers (pMDI) significantly improves lung drug delivery and reduces deposition in the mouth and stomach. This enhances the therapeutic efficacy of inhaled medications like salbutamol.

Area of Science:

  • Respiratory medicine
  • Pharmacology
  • Medical device engineering

Background:

  • Pressurized metered-dose inhalers (pMDI) require spacer devices to improve drug delivery to the lungs.
  • Spacer devices slow aerosol jets, reducing oropharyngeal deposition and coordination issues.
  • A new, less cumbersome spacer, the JET, was developed.

Purpose of the Study:

  • To evaluate the efficacy of the new JET spacer in improving lung deposition and reducing extrapulmonary deposition of salbutamol from a pMDI.
  • To compare drug delivery with and without the JET spacer in healthy volunteers.

Main Methods:

  • Five healthy volunteers inhaled 2 x 100 micrograms doses of 99mTc-labeled salbutamol via pMDI.
  • Inhalation was performed using a slow inspiratory vital capacity maneuver.

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  • Drug delivery was assessed with and without the JET spacer using scintigraphy.

    • Main Results:

    • Lung delivery of salbutamol increased from 14.3% to 22.3% with the JET spacer.
    • Extrapulmonary deposition (oropharynx and stomach) decreased from 39.8% to 11.0% with the JET spacer.
    • The JET spacer demonstrated a significant improvement in drug delivery efficiency.

    Conclusions:

    • The JET spacer effectively enhances therapeutic efficacy by increasing lung drug delivery and minimizing deposition in the upper airways and stomach.
    • Optimal use of the JET spacer is recommended for improved pMDI therapy.
    • Avoidance of holding chambers as reservoirs and frequent cleaning are advised.