[Effect of the thyroid in the development of intestinal hydroxylases]

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Updated: Oct 2, 2026

An Ex vivo Culture System to Study Thyroid Development
08:33

An Ex vivo Culture System to Study Thyroid Development

Published on: June 6, 2014

J M Castellanos Llorens

    Revista Iberica De Endocrinologia
    |May 1, 1976
    PubMed

    Insights

    This study tracks intestinal saccharidase activity in perinatal rats, finding sucrase and maltase increase with age while lactase declines. Thyroid hormone levels, crucial for fat digestion maturation, rise significantly after birth.

    Area of Science:

    • Physiology
    • Endocrinology
    • Developmental Biology

    Background:

    • Intestinal enzyme activity undergoes significant changes during development.
    • Thyroid hormones play a critical role in mammalian metabolic and digestive system maturation.

    Purpose of the Study:

    • To investigate the developmental patterns of saccharidase enzymes in the rat intestine during the perinatal period.
    • To assess the relationship between thyroid hormone levels and intestinal maturation.

    Main Methods:

    • Measurement of sucrase, maltase, and lactase activity in rat intestinal tissues.
    • Quantification of circulating thyroxine levels in blood samples from rats at various perinatal stages.

    Main Results:

    • Sucrase and maltase activities showed a progressive increase with age.
    • Lactase activity exhibited an age-dependent decrease.
    • Thyroxine levels were nearly undetectable at birth, rising sharply to adult levels by 22 days postpartum.

    Conclusions:

    • Intestinal saccharidase profiles change significantly during rat perinatal development.
    • Thyroid hormone levels increase substantially after birth and are implicated in intestinal maturation processes.

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