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Related Experiment Videos

13C breath test in gastroenterological practice

G R Swart1, J W van den Berg

  • 1Dept. of Gastroenterology and Hepatology, University Hospital Dijkzigt, Rotterdam, The Netherlands.

Scandinavian Journal of Gastroenterology. Supplement
|March 27, 1998
PubMed
Summary
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Breath tests (BTs) offer a safe, non-radioactive method to indirectly study gastrointestinal and metabolic processes. These semiquantitative tests measure metabolites in breath, replacing invasive procedures for conditions like H. pylori infection.

Area of Science:

  • Gastroenterology
  • Medical Diagnostics
  • Isotope Tracing

Background:

  • Breath tests (BTs) indirectly assess physiological and metabolic functions by analyzing breath metabolites.
  • The core principle assumes a rate-limiting step in tracer absorption and metabolism.

Purpose of the Study:

  • To review the applications and methodology of breath tests in gastroenterology.
  • To highlight BTs as a non-invasive alternative to invasive diagnostic procedures.

Main Methods:

  • Utilizes stable isotopes (e.g., 13C-labeled compounds) and mass spectrometry to measure metabolites in expired air.
  • Analyzes hydrogen gas excretion or carbon dioxide appearance in breath.

Main Results:

  • BTs provide semiquantitative data on gastric emptying, H. pylori presence, small-bowel bacterial overgrowth, pancreatic function, and liver capacity.

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  • Demonstrates the safety and efficacy of BTs by replacing invasive techniques.

    • Conclusions:

    • Breath tests are valuable, safe, and non-invasive diagnostic tools in gastroenterology.
    • BTs offer a practical approach for studying various gastrointestinal and metabolic conditions.