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Gastric asthma: a pathophysiological entity?

F T Peters1, J H Kleibeuker, D S Postma

  • 1Dept. of Gastroenterology, University Hospital Groningen, The Netherlands.

Scandinavian Journal of Gastroenterology. Supplement
|March 27, 1998
PubMed
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Gastro-oesophageal reflux disease (GORD) can worsen asthma symptoms in some patients through reflex or micro-aspiration. Identifying patients with difficult-to-treat or adult-onset asthma who also have GORD is key for effective treatment.

Area of Science:

  • Gastroenterology
  • Pulmonology
  • Internal Medicine

Background:

  • Gastro-oesophageal reflux disease (GORD) presents with typical and atypical symptoms, including respiratory conditions.
  • Gastric asthma is a significant extra-oesophageal manifestation of GORD, though its prevalence and importance are debated.

Purpose of the Study:

  • To review the literature on the relationship between GORD and asthma.
  • To discuss the prevalence, pathophysiology, and clinical significance of GORD in asthmatic patients.

Main Methods:

  • Narrative literature review.

Main Results:

  • GORD prevalence is higher in asthmatics, with a wide reported range.
  • GORD can aggravate or trigger asthma in a subset of patients via vagal reflex or micro-aspiration.

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  • Specific patient groups (difficult-to-treat, non-allergic, adult-onset asthma with GORD) may benefit from anti-reflux measures.

    • Conclusions:

    • GORD is an important consideration in asthma management, particularly for specific patient profiles.
    • Diagnostic tools like oesophageal pH-metry and gastroscopy are recommended for GORD confirmation and related complications.