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Treatment options for clinically recognized disseminated intravascular coagulation

M Riewald1, H Riess

  • 1Department of Hematology/Oncology, Virchow Klinikum, Humboldt University, Berlin, Germany.

Seminars in Thrombosis and Hemostasis
|March 27, 1998
PubMed

Insights

Disseminated intravascular coagulation (DIC) treatment requires identifying and treating the underlying cause. Therapeutic options include blood products, heparin, and newer agents to manage bleeding and clotting in this complex hemostatic disorder.

Area of Science:

  • Hematology
  • Internal Medicine

Background:

  • Disseminated intravascular coagulation (DIC) is a complex hemostatic disorder with heterogeneous causes and presentations.
  • Clinical symptoms range from bleeding and thromboembolism to organ failure, necessitating individualized treatment strategies.

Purpose of the Study:

  • To outline current concepts in DIC etiology and pathophysiology.
  • To discuss the principles and options for managing DIC based on clinical presentation and laboratory findings.

Main Methods:

  • Review of current understanding of DIC pathogenesis.
  • Analysis of established and emerging therapeutic interventions for DIC.

Main Results:

  • Treatment hinges on prompt identification and management of the underlying cause of DIC.
  • Therapeutic options include blood product transfusion, heparin, antithrombin III, antifibrinolytic agents, and newer drugs like activated protein C and tissue factor pathway inhibitor.

Conclusions:

  • Tailored treatment strategies are essential for managing DIC, considering its diverse clinical manifestations.
  • Ongoing research into novel and existing therapies will refine recommendations for DIC management across different etiologies.

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