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Short-term growth in asthmatic children using fluticasone propionate
M J Visser1, W M van Aalderen, B M Elliott
1Department of Pediatric Pulmonology, Beatrix Children's Hospital, University Hospital Groningen, The Netherlands.
Background:
Inhaled corticosteroids may reduce short-term growth velocity in asthmatic children and knemometry is the most sensitive tool to detect this short-term growth suppression.
Study Objective:
To compare lower leg growth velocity, as measured by knemometry, in asthmatic children during and after treatment with inhaled fluticasone propionate (FP), 100 microg twice daily.
Design:
Nonrandomized open trial.
Setting:
University hospital, outpatient clinic for pediatric pulmonology.
Patients:
Twenty-one asthmatic children (13 boys), aged 6 to 10 years.
Interventions:
Inhalation of FP from a dry powder inhaler, 100 microg, twice daily for 6 weeks, followed by 2 weeks during which only an inhaled beta2-agonist was used on demand (washout). During treatment and washout periods, patients were seen every 2 weeks at the same time of day.
Measurements And Results:
Lower leg growth velocity measured by knemometry during FP treatment was not significantly different from that during washout (p=0.33, one-way analysis of variance).
Conclusions:
No significant suppression of lower leg growth velocity was found in prepubertal asthmatic children using FP, 100 microg, by dry powder inhaler twice daily for 6 weeks.