Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Case report: cerebellar hemi-hypoplasia

J B Robins1, G C Mason, J Watters

  • 1Department of Feto-Maternal Medicine, The General Infirmary at Leeds, UK.

Prenatal Diagnosis
|March 27, 1998
PubMed
Summary

Unilateral cerebellar hypoplasia, a rare fetal brain abnormality, was identified prenatally. This case suggests a potential vascular cause, highlighting the importance of advanced imaging in diagnosing congenital brain defects.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Ultra-fast single-crystal CVD diamonds in the particle time-of-flight (PTOF) detector for low yield burn-history measurements on the NIF (invited).

The Review of scientific instruments·2025
Same author

Barriers to early detection: Insurance denials for breast MRI screening in women with germline BRCA1/2 mutations.

Gynecologic oncology·2025
Same author

Distribution and Characteristics of Congenital Cardiac Surgery Centers within Bangladesh.

Mymensingh medical journal : MMJ·2024
Same author

Achievement of Target Gain Larger than Unity in an Inertial Fusion Experiment.

Physical review letters·2024
Same author

Lawson Criterion for Ignition Exceeded in an Inertial Fusion Experiment.

Physical review letters·2022
Same author

Canadian Surgery Forum.

Canadian journal of surgery. Journal canadien de chirurgie·2022

Area of Science:

  • Neurology
  • Developmental Biology
  • Medical Imaging

Background:

  • Cerebellar hypoplasia is a significant finding in fetal brain pathology, often presenting as a generalized or symmetric defect.
  • Isolated or asymmetric cerebellar hypoplasia is uncommon, and its etiological factors are not fully understood.
  • The prevalence of cerebellar hypoplasia as a congenital defect in the human population remains undetermined.

Purpose of the Study:

  • To describe a unique case of unilateral cerebellar hypoplasia with an intact vermis detected during prenatal screening.
  • To investigate the potential disruptive vascular etiology of this specific cerebellar malformation.
  • To illustrate the utility of serial prenatal and postnatal imaging in characterizing fetal brain abnormalities.

Main Methods:

Related Experiment Videos

  • Prenatal ultrasound examination for initial detection of cerebellar hypoplasia.
  • Serial ultrasound assessments throughout gestation to monitor changes in the abnormality.
  • Post-delivery cranial ultrasound and Magnetic Resonance Imaging (MRI) for detailed anatomical evaluation.

    • Main Results:

    • A case of unilateral cerebellar hypoplasia, affecting one cerebellar hemisphere while sparing the vermis, was identified.
    • Dynamic changes observed in the fetal ultrasound suggested a process of destruction of previously normally formed cerebellar tissue.
    • Postnatal imaging confirmed the unilateral cerebellar hypoplasia and provided detailed structural information.

    Conclusions:

    • Unilateral cerebellar hypoplasia with an intact vermis is a rare presentation of fetal brain pathology.
    • The observed dynamic changes support a hypothesis of a disruptive vascular event as the etiology.
    • Advanced neuroimaging techniques are crucial for the diagnosis and characterization of congenital cerebellar malformations.