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Related Experiment Videos

Metoclopramide toxicity in an infant

K F Batts1, D W Munter

  • 1Emergency Medicine Department, Naval Medical Center, Portsmouth, Virginia 23708, USA.

Pediatric Emergency Care
|March 28, 1998
PubMed
Summary

Metoclopramide overdose in infants can cause serious extrapyramidal side effects. This case highlights the need for careful dosing in pediatric patients to prevent toxicity.

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Area of Science:

  • Pharmacology
  • Pediatric Medicine
  • Toxicology

Background:

  • Metoclopramide, a dopamine antagonist, is widely used in pediatrics for nausea and gastroesophageal reflux.
  • Its prokinetic and antiemetic properties stem from both central and peripheral actions.

Observation:

  • A six-month-old infant received a metoclopramide overdose of 24 mg (3 mg/kg) over nine hours.
  • The infant exhibited toxic extrapyramidal symptoms.

Findings:

  • Accidental metoclopramide overdose in infants can lead to severe extrapyramidal reactions.
  • This case represents a toxicity report not previously documented in emergency medicine literature.

Implications:

  • Emphasizes the critical need for precise metoclopramide dosing in pediatric patients.
  • Highlights potential risks of extrapyramidal symptoms in pediatric overdose cases.
  • Suggests increased awareness and vigilance regarding metoclopramide administration in infants.

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