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Lack of association between schizophrenia and HLA DQB1 alleles in a Swedish sample
E G Jönsson1, F Zhang, V L Nimgaonkar
1Department of Clinical Neuroscience, Psychiatry Section, Karolinska Institute, Stockholm, Sweden.
Schizophrenia Research
|March 28, 1998
Abstract:
Three studies have reported a negative genetic association between schizophrenia and HLA DQB1*0602, an allele of the human leucocyte antigen (HLA) DQB1*06 gene. In a sample of ethnic all homogeneous Caucasians living in Sweden, the frequency of HLA DQB1 alleles in patients with schizophrenia (n = 124) was compared with that in a control group (n = 85). No significant differences were found. Together with previous investigations, the present study indicates that the reported genetic association of DQB1*0602 with schizophrenia may be limited to non-Caucasians.