[Bone marrow cells of mice immunized with different rabies vaccines]

Cytogenetic studies of bone marrow cells of mice after inoculated differently with viral vaccines (fixed rabies virus, antirabic vaccine with the remainder virulence and fully inactivated with ultraviolet light antirabic vaccine) showed that all the vaccines, except the fully inactivated one, caused temporary damages of chromosomes interfering with the process of the first mitotic divisions after the beginning of immunization. The live fixed rabies virus caused a secondary, more significant increase in the frequency of chromosome aberrations at later periods of investigation (30-60 days after starting the experiments). The fluorescent antibody technique detected the specific fixed rabies virus antigen in the bone marrow cells of immunized animals within 3-90 days.