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Related Experiment Videos

Changes in plasma elastase during pregnancy and sub partu

T Cunze1, R Osmers, S Herzog

  • 1Department of Gynecology and Obstetrics, University of Göttingen, Germany.

Gynecologic and Obstetric Investigation
|March 28, 1998
PubMed
Summary

Plasma elastase, or EAPI, may not be a reliable marker for infection after membrane rupture. Serial monitoring of EAPI levels is recommended for more accurate detection of infection during pregnancy.

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Area of Science:

  • Biochemistry
  • Obstetrics
  • Immunology

Background:

  • Elastase, released by polymorphonuclear leukocytes (PNMs), is a potential infection marker, similar to C-reactive protein (CRP).
  • Alpha1-proteinase inhibitor deactivates elastase, forming detectable elastase-alpha1-proteinase inhibitor complexes (EAPI).
  • Previous studies suggested EAPI as an early marker for infection following premature rupture of membranes.

Purpose of the Study:

  • To investigate the diagnostic utility of plasma EAPI levels in healthy pregnant women and non-pregnant women.
  • To assess the correlation between plasma EAPI levels and labor progression, particularly in relation to membrane status.

Main Methods:

  • Plasma EAPI levels were analyzed in 335 healthy pregnant women and 47 healthy non-pregnant women.

Related Experiment Videos

  • EAPI levels were compared between non-pregnant women, pregnant women before labor, pregnant women at the start of labor, and women with advanced cervical dilation.

    • Main Results:

    • No significant differences in EAPI levels were observed in non-pregnant women or pregnant women until the onset of labor.
    • A significant increase in plasma EAPI was noted at the beginning of labor, even without membrane rupture (97.7 to 338.3 ng/ml).
    • EAPI concentrations decreased significantly once cervical dilation exceeded 2 cm, returning to pre-labor levels.

    Conclusions:

    • The findings suggest that elevated EAPI levels during labor onset are physiological and not necessarily indicative of infection or membrane rupture.
    • The utility of EAPI as a sole marker for infection after premature rupture of membranes may require re-evaluation.
    • Serial monitoring of plasma EAPI levels is recommended for more reliable detection of a persistent increase, potentially indicating infection.