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Related Experiment Videos

Heart rate variability in multiple sclerosis during a stable phase

J A Monge-Argilés1, F Palacios-Ortega, J A Vila-Sobrino

  • 1Department of Neurology, Hospital S. M. Rosell, Cartagena, Murcia, Spain.

Acta Neurologica Scandinavica
|March 28, 1998
PubMed
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Multiple sclerosis (MS) impairs cardiovascular autonomic regulation, affecting heart rate variability. MS patients show increased sympathetic tone and variable parasympathetic tone, which decreases with disease progression.

Area of Science:

  • Cardiovascular physiology
  • Autonomic nervous system function
  • Neurology

Background:

  • Multiple sclerosis (MS) commonly disrupts autonomic functions, particularly cardiovascular regulation.
  • Traditional autonomic tests and short-term heart rate variability (HRV) analysis have limitations in assessing cardiovascular dysautonomia in MS.
  • Long-term (24-hour) ECG recordings are recommended for more sensitive HRV analysis in MS.

Purpose of the Study:

  • To evaluate the impact of MS on sympathetic and parasympathetic cardiovascular regulatory functions.
  • To analyze heart rate variability (HRV) in time and frequency domains in MS patients compared to healthy controls.
  • To assess the relationship between MS severity and cardiovascular autonomic function.

Main Methods:

  • Analysis of heart rate variability (HRV) in time and frequency domains.

Related Experiment Videos

  • Utilized 24-hour electrocardiogram (ECG) recordings from 34 MS patients and 24 healthy controls.
  • Compared HRV parameters between MS patients and controls, and across different MS severity groups.

    • Main Results:

    • Significantly higher low frequency (LF) power and LF/HF power ratio in MS patients.
    • Increased very low frequency (VLF) and high frequency (HF) power in less affected MS patients.
    • Reduced time-domain variability in more affected MS patients, indicating autonomic dysfunction.

    Conclusions:

    • MS leads to cardiovascular autonomic dysregulation characterized by impaired HRV.
    • MS appears to increase sympathetic cardiovascular tone.
    • Parasympathetic tone in MS is variable, influenced by disease progression and clinical factors, tending to decrease with illness advancement.